Casey Kasem
— Shaggy Rogers (voice)
Jennifer Hale
— (voices)
Rachael MacFarlane
Ian James Corlett
— (voice)
Frank Welker
— Fred Jones / Scooby-Doo (voice)
Grey DeLisle
— Daphne Blake (voice)
Mindy Cohn
— Velma Dinkley (voice)
John Stephenson
— Bob Taylor (voice)
Tara Strong
John DiMaggio
— (voice)
Eddie Deezen
— Gibby Norton (voice)
Ron Perlman
— (voice)