George Clinton
— Host
Robert Guillaume
— Gleason Golightly (segment 'Space Traders')
Michele Lamar Richards
— Gail Golightly (segment 'Space Traders')
Jason Bernard
— Bernard Shields (segment 'Space Traders')
Edward Edwards
— Chief of Staff (segment 'Space Traders')
George Wallace
— Piggy (segment 'Space Traders')
Brian Reddy
— Vice President (segment 'Space Traders')
Larry Anderson
— Stryker O'Rourke (segment 'Space Traders')
Brock Peters
— Minister Coombs (segment 'Space Traders')
Bob Gunton
— President Ellis (segment 'Space Traders')
Nicholas Turturro
— Father Carlos (segment 'The First Commandment')
Efrain Figueroa
— Padrino (segment 'The First Commandment')
Richard Herd
— Cardinal (segment 'The First Commandment')
Paula Jai Parker
— Tang (segment 'Tang')
Chi McBride
— T-Bone (segment 'Tang')
Bertice Berry
— (segment 'Space Traders')
Franklin Cover
— (segment 'Space Traders')
Casey Kasem
— (segment 'Space Traders')
Roxie Roker
— (segment 'Space Traders')
Ebonie Smith
— Jennifer (segment 'Space Traders')
Craig Kirkwood
— Lenny (segment 'Space Traders')
Liz Larou
— Ute (segment 'Space Traders')
Jaye Koch
— Alien Press Secretary (segment 'Space Traders')
Marte Boyle Slout
— Helen Hipmeyer (segment 'Space Traders')
Joseph G. Medalis
— Defense Secretary (segment 'Space Traders')
James Noah
— Interior Secretary (segment 'Space Traders')
Tom Finnegan
— General Wright (segment 'Space Traders')
Arthur Burghardt
— Justin Jasper (segment 'Space Traders')
Roger Guenveur Smith
— Dr. Erik Fanon (segment 'Space Traders')
Roger Marks
— Rabbi Spector (segment 'Space Traders')