Colleen Moore
— Annie
Tom Santschi
— Dave Johnson
Harry Lonsdale
— Annie's Uncle
Eugenie Besserer
— Mrs. Goode
Doris Baker
— Orphan
Baby Lillian Wade
— Orphan
Ben Alexander
— Orphan
Billy Jacobs
— Orphan
George Hupp
— Orphan
Mae Gaston
— Annie's Mother
Lillian Hayward
— Aunt Elizabeth
Lafe McKee
— The Good Squire
Jean Stone
— Little Annie as a Child