James Franco
— Edward Fry
Camilla Belle
— Isabel Wallace
Summer Phoenix
— Beatrice Price
Michael Weston
— Tobias
Dominic Rains
— Dr. Benjamin Calhoun
Kai Lennox
— The Chairman
Alison Lees-Taylor
— Mary
George Basil
— Beatrice's Husband
Alan Bagh
— Orderly
Nicole Starrett
— Matron Phoebe Stokes
Carmen Argenziano
— Dr. Withers
Jennifer Daley
— Kara
Nina Ljeti
— Ethel
Jacquie Barnbrook
— Helga
Lori Jean Wilson
— Deirdre
Chantal Nchako
— Silla
Caige Coulter
— Rebecca
Vince Jolivette
— Board Member
Tamzin Brown
— Beatrice's Lover
Barbara Jill Small
— Bernadette
Carrie Gibson
— Freda
Emma Gojković
— Emma
Dawn Rasnick
— Dawn
Robert Bias
— Fry Carriage Driver
Lisa Goodman
— Griselda