John Ireland
— John Howard Barrington
Mercedes McCambridge
— Connie Carter
James Barton
— Ezra Thompson
Emlyn Williams
— Dr. David Dunbar
Lloyd Gough
— Asylum Dr. Gordon
Basil Ruysdael
— Cyrus Barrington
David Bauer
— Level Louie
Harry Shannon
— Asylum Warden Anderson
Celia Lovsky
— Mrs. Cyrus Barrington
David McMahon
— State Trooper
Chubby Johnson
— Feed Store Manager
Frank Jenks
— Tom, Drunk Cowboy
Emmett Lynn
— Jack, Waiter
Dick Wessel
— Sid, Drunk Cowboy
Frank Jaquet
— Town Sheriff
Lyle Talbot
— City Detective
King Donovan
— Piano Player
O.Z. Whitehead
— Whoopie
Frank Richards
— Gargantua
Sue Casey
— Miss Dean, Receptionist
Iris Adrian
— Floozy at Level Louie's Place
Richard Alexander
— Barfly
Barry Brooks
— Hospital Prison Guard
John Frederick
— Deputy
Frank Hagney
— Floozy's Boyfriend
Tom Kennedy
— Asylum Inmate
Paul Kruger
— Police Detective