Tom Cavanagh
— Mal Downey
Sarah Chalke
— Samantha Rose
James Barbour
— Dr. Troy Rollins
Michael Ian Black
— Jerry (voice)
Nadia Dajani
— Jane
Illeana Douglas
— KJ
Celeste Holm
— Iris
Logan Marshall-Green
— Martin
Wil Horneff
— Dave
Shannon McGinnis
— Barbara
Anna Belknap
— Marissa
Tovah Feldshuh
— Senior Editor
Daphne Rubin-Vega
— Belladonna Editor
Susan Misner
— Associate Editor
Erik Palladino
— Groom
Catherine Kellner
— Bride
Ajay Naidu
— Best Man
Marisa Ryan
— Bridesmaid
Stephen Bogardus
— Father of Bride
Daniel Cantor
— Philly Phil
Ann McDonough
— Mother of Bride
Zack Abramowitz
— Restaurant Patron (uncredited)
Bryan Ayres
— Angry Student
Gavin Bailey
— Martin's Best Man
Michele Buster
— Other Voice (Voice)
Julien David
— Giscard
Terrence Gray
— Wedding Spectator
Sophocles Jones
— Pedestrian
Andy Kris
— Other Voice (Voice)
Lia Levenson
— Italian Ice Mom