David Kaufman
— Daniel "Danny" Fenton / Danny Phantom (voice)
Grey DeLisle
— Samantha "Sam" Manson (voice)
Rickey D'Shon Collins
— Tucker Foley (voice)
Colleen O'Shaughnessey
— Jasmine "Jazz" Fenton (voice)
Rob Paulsen
— Jack Fenton (voice)
Kath Soucie
— Maddie Fenton (voice)
María Canals Barrera
— Paulina (voice)
Kimberly Brooks
— Mrs. Foley (voice)
S. Scott Bullock
— Dash Baxter / Mr. Jeremy Manson / Operative O (voice)
Jon Cryer
— Freakshow (voice)
Phil LaMarr
— Mr. Maurice Foley (voice)
Laraine Newman
— Mrs. Pamela Manson (voice)
Jim Ward
— Operative L (voice)