Robert Alda
— George Gershwin
Joan Leslie
— Julie Adams
Alexis Smith
— Christine Gilbert
Charles Coburn
— Max Dreyfus
Julie Bishop
— Lee Gershwin
Albert Bassermann
— Prof. Franck
Morris Carnovsky
— Morris Gershwin
Rosemary DeCamp
— Rose Gershwin
Oscar Levant
— Oscar Levant
Paul Whiteman
— Paul Whiteman
Al Jolson
— Al Jolson
George White
— George White
Hazel Scott
— Hazel Scott
Anne Brown
— Bess
Herbert Rudley
— Ira Gershwin
John B. Hughes
— Hughes
Mickey Roth
— George Gershwin as a Boy
Darryl Hickman
— Ira Gershwin as a Boy
Charles Halton
— Mr. Kast
Andrew Tombes
— Mr. Million
Gregory Golubeff
— Mr. Katzman
Walter Soderling
— Mr. Muscatel
Eddie Marr
— Buddy De Sylva
Theodore von Eltz
— Foley
Bill Kennedy
— Herbert Stone
Oscar Loraine
— Maurice Ravel
Johnny Downs
— Dancer
Ernest Golm
— Otto Kahn
Martin Noble
— Jascha Heifetz
Hugo Kirchhoffer
— Walter Damrosch