Irene Dunne
— Ann Vickers
Walter Huston
— Barney Dolphin
Conrad Nagel
— Lindsey Atwell
Bruce Cabot
— Captain Lafe Resnick
Edna May Oliver
— Malvina Wormser
Sam Hardy
— Russell Spaulding
Mitchell Lewis
— Captain Waldo
Murray Kinnell
— Dr. Slenk - Copper Gap Warden
Helen Eby-Rock
— Kitty Cognac
Gertrude Michael
— Mona Dolphin
J. Carrol Naish
— Dr. Sorelle
Sarah Padden
— Lil
Reginald Barlow
— Chaplain
Rafaela Ottiano
— Mrs. Feldermans
Wally Albright
— Mischa Feldermans (uncredited)
Margaret Armstrong
— Miss Jones (uncredited)
Irving Bacon
— Waiter (uncredited)
May Beatty
— Nurse (uncredited)
Katherine Block
— Prison Matron (uncredited)
Estelle Brody
— Prisoner (uncredited)
William P. Carleton
— Bit Part (uncredited)
Jimmy Casey
— Reporter (uncredited)
Bill Cody
— Guard (uncredited)
Helen Cromwell
— Mrs. Bingham (uncredited)
John Cromwell
— Sad Faced Doughboy (uncredited)
Jenny Dark
— Prisoner (uncredited)
Jane Darwell
— Mrs. Gage (uncredited)
Robert Doran
— Bit Part (uncredited)
Mary Foy
— Big Prison Matron in Warden's Office (uncredited)
Jack Gargan
— Bit Part (uncredited)