Steve Oedekerk
— The Godthumb / Johnny Paesano / Italian Man (voice)
Megan Cavanagh
— Bea / Conceited / Old Italian Woman
Cam Clarke
— Adopted Lawyer Son / Mr. Henderson
Mark DeCarlo
— Thummy / Don Bazzarzini / Wartz
Paul Greenberg
— Afraido / Badgerburger Waiter / Elevator Thumb
Rob Paulsen
— Mickey / Toll Booth Operator
Eric Trueheart
— Doctor
Jim Jackman
— Lucky Brassiere / Joey Carbone / Thumb in Stall