Gugu Mbatha-Raw
— Abbie
Michiel Huisman
— Sam
Steve Coogan
— Mitch
Timothy Simons
— Dominic
Jacki Weaver
— Estelle
Kate McKinnon
— Glass Half Full Kate
Christopher Walken
— Myron
Zach Cherry
— Jim
Jessie Ennis
— Melanie
Glenn Fleshler
— Mean Phil
Zabryna Guevara
— Dr. Michaelson
Brian Tyree Henry
— Benji
Rick Holmes
— Dr. Kessler
Alanna Masterson
— Sally
Gayle Rankin
— Mira
Erin Richards
— Amber
Tami Sagher
— Meryl
Tamara Tunie
— Jane
Merritt Wever
— Mindy
Alyssa Cheatham
— Young Abbie
Celeste O'Connor
— Teen Abbie
Zachary Hernandez
— Young Sam
Sawyer Barth
— Teen Sam
Michael Gaston
— Crochet Master
Angelo Anthony Pizza
— Blonde Kid
Vanessa Carrasco
— Naughty Kid
Edan Alexander
— Cute Little Kid
Alexa Tropper
— Awkward Girl
Grace Rex
— Interviewee