Ben Stiller
— Derek Zoolander (voice)
Owen Wilson
— Hansel (voice)
Patton Oswalt
— Dr. Botoxo (voice)
Jenny Slate
— Nani (voice)
Nick Kroll
— Frankie J-PEG (voice)
Tim Gunn
— Tim Gunn (voice)
Christine Taylor
— Matilda Jeffries (voice)
Jerry Stiller
— Maury Ballstein (voice)
Rashida Jones
— D'Jangelo (voice)
Andy Daly
— Nani's Dad (voice)
Julie Klausner
— (voice)
Jon Daly
— The Paparocto (voice)
James Adomian
— (voice)
Leighton Meester
— Leighton Meester (voice)
Heidi Klum
— Heidi Klum (voice)
Kim Kardashian
— Kim Kardashian (voice)
Khloé Kardashian
— Khloé Kardashian (voice)
Katy Perry
— Katy Perry (voice)