Kamal Haasan
— 'Vasool Raja' Rajaraman Venkatraman
Prakash Raj
— Dr. Vishwanathan
Prabhu
— Vatti
Sneha
— Janaki 'Paapu' Vishwanathan
Nagesh
— Sriman Venkatraman
रोहिणी हट्टंगड़ी
— Kasturi
Crazy Mohan
— Professor Margabandhu
Karunas
— Amit
Jayasurya
— Zakir
Malavika
— Priya
Ajay Rathnam
— Medicine Professor
Kavithalaya Krishnan
— Surgery Professor
Nithin Sathya
— Neelakandan
Chitra Lakshmanan
— Dr. Kalidas
Thalaivasal Vijay
— Doctor
Santhana Bharathi
— Gangadharan
Kaaka Radhakrishnan
— Margabandhu's father
A. K. Veerasamy
— Hospital cleaner
Madhan Bob
— Mani Raja
Vaiyapuri
— Piles Patient
E. Ramadoss
— Ward Boy
Karate Raja
— Raja's sidekick
Sampath Ram
— Raja's sidekick
Meera Krishnan
— Mani Raja's wife
Kaajal Pasupathi
— Nurse
Boys Rajan
— Professor
Yatin Karyekar
— Anand
Benjamin
— Pickpocket
Scisor Manogar
Rathina Sabapathy
— Swaminathan