Catherine Keener
— Amelia
Anne Heche
— Laura
Todd Field
— Frank
Liev Schreiber
— Andrew
Kevin Corrigan
— Bill
Amy Braverman
— Young Amelia
Miranda Rhyne
— Young Laura
Randall Batinkoff
— Peter
Brenda Denmark
— The Vet
Vincent Pastore
— Laura's Devil-Seeing Patient
Joseph Siravo
— Amelia's Therapist
Rafa Alvarez
— Laura's Sexy Patient
Ritamarie Kelly
— Ellen
Steve Cohen
— Actor In Play
Jordan Levinson
— Peter's Friend
Heather Gottlieb
— Amelia's Co-Worker
Lynn Cohen
— Andrew's Mom
Lawrence Holofcener
— Andrew's Dad
Nitza Wilon
— Cat Sympathizer
Allison Janney
— Gum Puller
Alice Drummond
— Betsy
Bettina Skye
— Virginia
Michael Kroll
— Rick
Isa Thomas
— Aunt Cynthia