Babe Ruth
— Babe Dugan
Anna Q. Nilsson
— Vernie
Louise Fazenda
— Laundry Girl
Ethel Shannon
— Georgia
Arthur Stone
— Laundry-Truck Driver
Lou Archer
— Peewee
Tom McGuire
— Angel
Mickey Bennett
— Mascot
James Bradbury Sr.
— Baseball Player
Guinn 'Big Boy' Williams
— Baseball Player (as Big Boy Williams)
James Gordon
— Baseball Player
Ralf Harolde
— Baseball Fan (uncredited)
Helen Parrish
— Young Girl (uncredited)