Casey Kasem
— Shaggy (voice)
Grey DeLisle
— Daphne (voice)
Mindy Cohn
— Velma (voice)
Kathy Kinney
— Sheriff Ellen Perkins (voice)
Frank Welker
— Fred / Scooby-Doo / Headless Snowman (voice)
Peter Scolari
— Professor William Fagen Higginson (voice)
Mark Hamill
— Tommy's Father (voice)
Daryl Sabara
— Tommy (voice)
Jim Belushi
— Asa Buckwald (voice)