Charles Hill Mailes
— Mexican Jim
Claire McDowell
— Mexican Jim's Wife
Blanche Sweet
— Alice Hardy - the Prospector's Wife
W. Chrystie Miller
— The Murdered Indian / Indian on Street
Robert Harron
— The Murdered Indian's Son
Mae Marsh
— A Murdered Settler (uncredited)
Alfred Paget
— A Drunken Cutthroat / An Indian / Among Rescuers (uncredited)
Jack Pickford
— An Indian (uncredited)
Charles Gorman
— Jack Hardy - the Prospector
Frank Opperman
— The Indian Chief / A Drunken Cutthroat / Bartender (uncredited)
Christy Cabanne
— An Indian (uncredited)
William A. Carroll
— In Bar / Among Rescuers (uncredited)
Frank Evans
— In Bar / Among Rescuers (uncredited)
Bert Hendler
— In Bar (uncredited)
Harry Hyde
— Among Rescuers / Outside Pony Express Office (uncredited)
J. Jiquel Lanoe
— An Indian / Among Rescuers (uncredited)
Wilfred Lucas
— An Indian (uncredited)
W.C. Robinson
— An Indian / In Bar / Among Rescuers (uncredited)
Charles West
— Undetermined Role (uncredited)