Helen Hayes
— Lucille Jefferson
Van Heflin
— Stedman
Dean Jagger
— Dan Jefferson
Robert Walker
— John Jefferson
Minor Watson
— Dr. Carver
Frank McHugh
— Father O'Dowd
Richard Jaeckel
— Chuck Jefferson
James Young
— Ben Jefferson
Jimmie Dundee
— Taxi Driver (uncredited)
Douglas Evans
— Government Employee (uncredited)
Nancy Hale
— Nurse (uncredited)
Sam Harris
— Professor at Graduation Ceremony (uncredited)
Todd Karns
— Bedford (uncredited)
Leo McCarey
— John Jefferson (voice) (uncredited)
Lee Miller
— Policeman at Shooting Scene (uncredited)
David Newell
— FBI Agent (uncredited)
Vera Stokes
— Secretary (uncredited)
Fred Sweeney
— Cleaner (uncredited)
Margaret Wells
— Nurse (uncredited)