Kath Soucie
— Anita Dearly / Rolly / Cadpig (voice)
Tara Strong
— Spot / Two-Tone / Vendela (voice) (as Tara Charendoff)
Jeff Bennett
— Roger Dearly / Lt. Pug / Sgt. Tibbs / Swamp Rat / P.H. DeVil (voice)
April Winchell
— Cruella de Vil (voice)
Frank Welker
— Scorch / Steven the Aligator (voice)
Kevin Schon
— Pongo (voice)
Pam Dawber
— Perdy (voice)