Mark Rendall
— Arthur Read (voice)
Jodie Resther
— Francine Frensky (voice)
Melissa Altro
— Muffy Crosswire (voice)
Bruce Dinsmore
— David Read / Binky Barnes (voice)
Holly Gauthier-Frankel
— Fern Walters (voice)
Maggie Castle
— Molly MacDonald (voice)
Bronwen Mantel
— Mrs. MacGrady (voice)
Nick Carter
— Self - Backstreet Boys (voice)
Howie Dorough
— Self - Backstreet Boys (voice)
Brian Littrell
— Self - Backstreet Boys (voice)
Kevin Richardson
— Self - Backstreet Boys (voice)
AJ McLean
— Self - Backstreet Boys (voice)
Jason Szwimmer
— Dora Winifred 'D.W.' Read (voice)
Daniel Brochu
— Buster Baxter (voice)
Sonja Ball
— Jane Read (voice)
Tracy Braunstein
— Kate Read (voice)
Ellen David
— Bitzi Baxter (voice)
A.J. Henderson
— Ed Crosswire (voice)
Arthur Holden
— Mr. Ratburn (voice)
Jonathan Koensgen
— Tommy Tibble (voice)
Samuel Holden
— Timmy Tibble (voice)
Alex Hood
— Alan 'The Brain' Powers (voice)
Kate Hutchison
— Paige Turner (voice)
Tamar Kozlov
— Prunella Deegan (voice)
Greg Kramer
— Nemo (voice)
Vanessa Lengies
— Emily (voice)
Walter Massey
— Principal Haney (voice)
Joanna Noyes
— Grandma Thora Read (voice)
Simon Peacock
— Pal (voice)
Hayley Reynolds
— Nadine (voice)