Sean Astin
— Randall P. McDuff / Josiah (voice)
Pamela Hayden
— Sublimity Jill / Daughter #2 (voice)
Scott Lawrence
— Lewis Clark Jefferson / Cowpoke #3 (voice)
Maurice LaMarche
— Bumpy Snits / Ferryman #1 / Cowpoke #2 (voice)
Carolyn Lawrence
— Ornery Sue / Wagonmaster's Wife / Daughter #3 (voice)
Craig Bartlett
— Romeo Jones / Ferryman #2 / Cheyenne #1 (voice)
Andrea Bowen
— Billie Bartley / Manifest Destiny (voice)
Josh Hutcherson
— Toad E. Bartley (voice)
Dan Conroy
— Wagonmaster / Pioneer #1 / Cowpoke #1 (voice)
Danny Mann
— Three-Eyed Jack / Wall-Eyed Tom (voice)
Christie Insley
— Daughter #1 (voice)
Dan Castellaneta
— Wild Bill Hickok / Clerk / Cheyenne #2 (voice)