ఓ! బేబీ

Samantha Ruth Prabhu

— Swathi "Baby" / Savitri

Lakshmi

— Savitri "Baby"

Rajendra Prasad

— Pasupuleti Kanakaraju "Chanti"

Rao Ramesh

— Shekar "Nani"

Teja Sajja

— Rocky

Urvashi

— Sulochana

Naga Shaurya

— Vikram

Aishwarya Bhaskar

— Vikram's Mother

Aneesha Dama

— Divya

Raja Ravindra

— Sarma

Jagapati Babu

— Mysterious Person

Sunaina Badam

— Chanti's Daughter

RJ Hemant

— Vikram's Friend

Adivi Sesh

— Savitri’s husband

Naga Chaitanya Akkineni

— Young Chanti

Suma Kanakala

— TV Anchor

B. V. Nandini Reddy

— Doctor