Janet McTeer
— Professor Lily Penleric, PhD
Michael Goodwin
— Professor Wallace Aldrich, PhD
Gregory Russell Cook
— Fate Honeycutt
Jane Adams
— Eleanor 'Elna' Penleric
E. Katherine Kerr
— Harriet Tolliver
Emmy Rossum
— Deladis Slocumb
Pat Carroll
— Viney Butler
Stephanie Roth Haberle
— Alice Kincaid
Aidan Quinn
— Tom Bledsoe
Bart Hansard
— Hilliard
Erin Blake Clanton
— Polly
David Patrick Kelly
— Earl Giddens
Kristin Hall
— Isabel
Michael Harding
— Reese Kincaid
Taj Mahal
— Dexter Speaks
Iris DeMent
— Rose Gentry
Rhoda Griffis
— Clementine McFarland
Michael Davis
— Dean Arthur Pembroke
Steve Boles
— Ambrose McFarland
Taylor Hayes
— Reverend Merriweather
Josh Goforth
— Will
Don Pedi
— Barn Band - Dulcimer
Sheila Kay Adams
— Barn Band - Banjo
Bobby McMillon
— Singer at Barn Dance
Hazel Dickens
— Singer at Barn Dance
Andrea Powell
— Josie Moore
Danny Nelson
— Uncle Cratis
David Ducey
— Postman Johnson
Steven Sutherlan
— Cyrus Whittle