Jack Kerouac
— Narrator (voice)
Allen Ginsberg
— Alan
Gregory Corso
— Gregory
Peter Orlovsky
— Peter
Larry Rivers
— Milo
David Amram
— Mez McGillicuddy
Richard Bellamy
— Bishop
Alice Neel
— Bishop's Mother
Sally Gross
— Bishop's Sister
Pablo Frank
— Pablo, Milo's Son
Delphine Seyrig
— Milo's Wife
Denise Parker
— Girl in Bed