Franco Nero
— Keoma
William Berger
— William John Shannon
Olga Karlatos
— Liza Farrow
Orso Maria Guerrini
— Butch Shannon
Gabriella Giacobbe
— The Witch
Antonio Marsina
— Lenny Shannon
Joshua Sinclair
— Sam Shannon
Donald O'Brien
— Caldwell
Leonardo Scavino
— Doctor
Wolfango Soldati
— Wolf
Victoria Zinny
— Saloon Hooker
Alfio Caltabiano
— Clay
Woody Strode
— George
Roberto Dell'Acqua
— Jeff (uncredited)
Riccardo Pizzuti
— Slade (uncredited)
Pierangelo Civera
— Plague Victim (uncredited)
Ian Danby
— Saloon Bartender (uncredited)
Catharina Dahlin
— Woman Receiving Medicine (uncredited)
Massimo Vanni
— Caldwell's Henchman at Wagon (uncredited)
Sergio Ruggeri
— Caldwell's Henchman at Saloon (uncredited)
Giovanni Cianfriglia
— Caldwell's Henchman (uncredited)
Franco Ukmar
— Caldwell's Henchman (uncredited)
Angelo Ragusa
— Caldwell's Henchman (uncredited)
Antonio Basile
— Caldwell's Henchman (uncredited)
Giovanni Ukmar
— Caldwell's Henchman (uncredited)
Augusto Funari
— Caldwell's Henchman (uncredited)
Roberto Messina
— Caldwell's Henchman (uncredited)
Giovanni Bonadonna
— Caldwell's Henchman (uncredited)
Aldo Canti
— Caldwell's Henchman (uncredited)
Sergio Ukmar
— Caldwell's Henchman (uncredited)