Pete Davidson
— Marmaduke (voice)
J.K. Simmons
— Zeus (voice)
David Koechner
— Phil Winslow (voice)
Mary Hart
— EntertainMutt Tonight Host (voice)
Julie Nathanson
— Dottie Winslow (voice)
Terri Douglas
— Billy Winslow (voice)
Erin Fitzgerald
— Barbara Winslow (voice)
Stephen Stanton
— King Tut (voice)
Brian Hull
— Guy Hilton (voice)
Sumalee Montano
— Amy (voice)
Andrew Morgado
— Henri / Phillipe (voice)
Chris Hackney
— Announcer (voice)
Shelby Young
— Shantrelle (voice)
Johnny Yong Bosch
— Zhi (voice)
Nika Futterman
— Juan Pedro (voice)
Melissa Disney
— Javier (voice)
Fred Tatasciore
— Vinnie (voice)
Jason Anthony
— Ronnie (voice)
Vanessa Marshall
— Phone Girl (voice)
Nickie Bryar
— Derek (voice)
Joey Camen
— Bee (voice)
Rene Mujica
— Clown (voice)
Sean Rohani
— Butcher (voice)
Joey D'Auria
— Shar Pei (voice)
Cellin Gluck
— Male Judge (voice)
Tania Gunadi
— Cheerleader #1 (voice)
Rachelle Heger
— Cheerleader #2 (voice)
Jason Pace
— Capt. Jake S. Dean (voice)
Sarah Jean Pace
— Chloe Laureno (voice)
Sabra May
— Additional Voices (voice)