Dhanush
— Sivaramakrishnan / Dhandapani
Genelia D'Souza
— Pooja Padmanadhan
Vivek
— 'Emotional' Ekambaram
K. Bhagyaraj
— Raghupathi/Washington Vetrivel
Ashish Vidhyarthi
— Periyamuthu Gounder
Jayaprakash Reddy
— Chinnamuthu Gounder
R. Sundarrajan
— Sundaram
Karunas
— Janaki
Vijay Babu
— Raghavan / Chicago Shakthivel
Charu Haasan
— Swamiji
Mayilsamy
— Santhosh Kanth
Srinath
— David
Pandu
— Swamiji's Assistant
Rajendran
— Velu
Ambika
— Sivakaami
Rekha
— Meenakshi
Rajyalakshmi
— Lakshmi Raghupathi
Nithya
— Bharatham Sundaram
Uma Padmanabhan
— Sundari Raghavan
Aarthi
— Raji/Gundumani
Surekha Vani
— Chinnamuthu's daughter-in-law
Shriya Saran
— Kalpana (Guest Appearance)