Steve Carell
— Mark (segment "Street of Pain")
James Gandolfini
— The Man (segment "Club Soda")
Josh Hartnett
— Gianni (segment "Member")
Paul Walker
— Mikey (segment "Life Makes Sense If You're Famous")
Paris Hilton
— Sadie (segment "L.A. Knights")
Scott Caan
— Hayden Field (segment "Life Makes Sense If You're Famous")
Joe Mantegna
— Mike (segment "Club Soda")
Desmond Harrington
— Jay (segment "Life Makes Sense If You're Famous")
Steven R. McQueen
— The Kid (segment "Club Soda")
Will McCormack
— Dean (segment "Life Makes Sense If You're Famous")
Laurie Fortier
— Bunny (segment "Club Soda")
Michael Rispoli
— Jack (segment "Club Soda")
Louis Gossett Jr.
— Doc (segment "Club Soda")
Erik MacArthur
— Owen Peedmen (segment "Life Makes Sense If You're Famous")
Ian Gomez
— Beau (segment "Street of Pain")
Eric Stonestreet
— Floyd (segment "Street of Pain")
Ken Hudson Campbell
— Chester (segment "Street of Pain")
Ioan Gruffudd
— Simon (segment "The Little Things")
Alisen Down
— Claire (segment "The Little Things")
Aaron Douglas
— The Boss (segment "The Little Things")
Alistair Abell
— Bob (segment "The Little Things")
Jason Shaw
— Fantasy Guy (segment "L.A. Knights")
Kathleen Campbell
— Cheryl (segment "Street of Pain")
Fanshen Cox
— Maximina (segment "L.A. Knights")
Sole Alberti
— Lou (segment "L.A. Knights")