'Weird Al' Yankovic
— Self / Phineas Gage
Billy West
— Norm the Owl / Billy the Brain
Tim Heidecker
— Brain Stretcher
Eric Wareheim
— Brain Stretcher
Patton Oswalt
— Co-Worker
Thomas Lennon
— Co-Worker
Paul McCartney
— Man on the Street
Fabio
— Man on the Street
Bob Bancroft
— Norm Kozlovsky
Michael William Arnold
— Timmy
Ezra Buzzington
— Homeless Guy