Blythe Danner
— Bee Bedloe
Edward Herrmann
— Doug Bedloe
Melina Kanakaredes
— Rita
Tom McCarthy
— Ian Bedloe
Jeffrey Nordling
— Danny Bedloe
Mary-Louise Parker
— Lucy Dean Bedloe
Rene Augesen
— Adult Agatha
Amy Hargreaves
— Adult Daphne
Bethel Leslie
— Mrs. Dulcimer
Glynnis O'Connor
— Claudia Bedloe
Denis O'Hare
— Reverend Emmett
Kristoffer Ryan Winters
— Adult Thomas
Mary Lucy Bivins
— Mrs. Jordan
Lori Rom
— Cicely Brown
Hallee Hirsh
— Young Agatha
Sam Gyllenhaal
— Young Thomas
Julia McClernon
— Young Daphne
Tracy Spindler
— Agatha 12 Years
Joseph Cross
— Thomas 10 Years
Heather Adams
— Baby Daphne
Shannon Adams
— Baby Daphne
Bill Raymond
— B.B. Brandt
Molly Price
— Clara
Pamela Gray
— Dot
Ginnie Randall
— Mrs. Myrdal
Erik Frey
— Gideon (uncredited)
Dennis Gomez
— Church Pianist (uncredited)
Michael Harding
— Neighbor (uncredited)
Sang-Ho Lee
— Medical Student (uncredited)
Lorri Lindberg
— Churchwoman (uncredited)