Patricia Clarkson
— Mia
Rosario Dawson
— Lili
Lyndsy Fonseca
— Cheyanne
Ginnifer Goodwin
— Charlotte
Jeanne Tripplehorn
— Pearl
Emily Skinner
— Sally
Carla Gallo
— Laura
Aisha Hinds
— Bernice
Josh Holloway
— Bill
Jennifer Morrison
— Sheila
Austin Nichols
— Edward
Annie Potts
— Helen
Xander Berkeley
— Peter
Kathy Najimy
— Rocky
Romy Rosemont
— Lynne
Tony Shalhoub
— Mitch
Jenifer Lewis
— Maggie
Tracee Ellis Ross
— Alyssa
Jeffrey Tambor
— Danny
David Eigenberg
— Lenny
Taylor Kinney
— Tommy
Casey Simpson
— Buddy
Bob Newhart
— Dr. Roth
Ravi Patel
— Dr. Desai
Alan Ruck
— Sam Jarente
Scott Wilson
— Bill (Older)
Kirk Baily
— Scott
Israel Sáez de Miguel
— Dimitri
Ava Acres
— Pearl at age 7
Josh Dallas
— Henry