Mitchell Hoog
— Narrator
Krista Allen
— Diane (Quarentales Segment)
Eric Roberts
— Russell (Quarantales Segment)
Eliza Roberts
— Debbie (Quarantales Segment)
Robert Picardo
— Dr. Robinson (Past Cure Segment)
Tionne Watkins
— Cheryl
Debra Wilson
— Pam (Quarantales Segment)
Michael Welch
— Allen (Quarantales Segment)
Frances Lee McCain
— 'Bubbie' Lieberman (Ushering the Light)
Amber Lynn Ashley
— Alisha (Quarantales Segment)
Jason Potter
— Andy (Quarantales Segment)
Ted Maritz
— Rexton (Quarantales Segment)
Brian McCulley
— Trenton Wells (Quarantales Segment)
John Crockett
— Neighbor (Quarantales Segment)
Pari Roehi
— Abby