Akio Ōtsuka
— Solid Snake (voice)
Hideyuki Tanaka
— Hal 'Otacon' Emmerich (voice)
Takeshi Aono
— Roy Campbell (voice)
沢木郁也
— Ocelot (voice)
Kyoko Terase
— Meryl (voice)
Hiromi Tsuru
— Naomi Hunter (voice)
Hōko Kuwashima
— Mei Ling (voice)
Masaharu Satō
— Donald Anderson (voice)
Takumi Yamazaki
— Cyborg Ninja (voice)
Banjō Ginga
— Liquid Snake / Master Miller (voice)
家中宏
— Psycho Mantis (voice)
Naoko Nakamura
— Sniper Wolf (voice)
堀之紀
— Vulcan Raven (voice)
藤本譲
— Kenneth Baker (voice)
麻生智久
— Jim Houseman (voice)
小松里歌
— Others (voice)
今村直樹
— Others (voice)
平井啓二
— Others (voice)
Keisuke Baba
— Others (voice)
Takehiko Watanabe
— Others (voice)
森岳志
— Others (voice)
Takahiko Sakaguma
— Others (voice)