Akio Ōtsuka
— Solid Snake / Solidus Snake (voice)
田中英行
— Hal 'Otacon' Emmerich (voice)
Takeshi Aono
— Roy Campbell (voice)
沢木郁也
— Ocelot (voice)
Takumi Yamazaki
— Cyborg Ninja (voice)
Banjō Ginga
— Liquid Snake (voice)
山本麻里安
— Emma Emmerich (voice)
Kikuko Inoue
— Rosemary (voice)
Shōzō Iizuka
— Peter Stillman (voice)
Ryōtarō Okiayu
— Vamp (voice)
Kenyu Horiuchi
— Raiden (voice)
Yumi Tōma
— Fortune (voice)
塩屋浩三
— Fatman (voice)
阪脩
— Sergei Gurlukovich (voice)
Daisuke Gouri
— Scott Dolph (voice)
Kyoko Terase
— Olga Gurlukovich (voice)
堀之紀
— The Sorrow (voice)
藤本譲
— President Johnson (voice)
小松里歌
— Others (voice)
今村直樹
— Others (voice)
平井啓二
— Others (voice)
Keisuke Baba
— Others (voice)
Takehiko Watanabe
— Others (voice)
森岳志
— Others (voice)
Takahiko Sakaguma
— Others (voice)