Rosemarie DeWitt
— Cindy Lamson
Ron Livingston
— Jim Lamson
Mary-Louise Parker
— Roxy
Elaine May
— Ruth Lipsman Berg
Sandra Oh
— Grace Park
Moses Ingram
— Audre Robinson
Noma Dumezweni
— Dionne Davis
Raúl Castillo
— Nurse Joey
Alison Pill
— Bridget Salt
John Gallagher Jr.
— Dale Salt
Daphne Rubin-Vega
— Lupe Ramirez
Joshua Leonard
— Doug Salt
Jin Ha
— Elliot Park
Judith Light
— Shirlee Salt
Ato Blankson-Wood
— Russell Davis
Cory Michael Smith
— Jeremy Salt
Rhenzy Feliz
— Jose Sera
Camila Perez
— Frieda Ramirez
K. Todd Freeman
— Leon Robinson
Danny Burstein
— Dr. Daniel Berg
Joel de la Fuente
— John Park
Raza Jaffrey
— Dr. Sanjay Patel
Brittany Bradford
— Imani Hart
David Zaldivar
— Mateo Ramirez
Willa Cuthrell-Tuttleman
— Amy
Tim Guinee
— Phil H.
Jorge Charbonier
— Grandpa Alfredo
Bill Timoney
— News Reporter (voice)
Gamze Ceylan
— Jackie
Chris Hotlkamp
— John