John Liu
— John Liu / The Ninja
Don Wilson
— John Liu / The Ninja (voice)
Adrienne Meltzer
— Randi Rydell
Linnea Quigley
— Randi Rydell (voice)
Vince Murdocco
— Jack "The Cameraman" (voice)
Leon Isaac Kennedy
— Det. Jimmy Williams (voice)
Cynthia Rothrock
— Det. Janet Flores (voice)
Michael Berryman
— The Plutonium Killer (voice)
Matt Mitler
— Freddy Cufflinks (voice)
Ginger Lynn
— Nita Liu (voice)
Zihan Zhao
— The Kid (voice)
Bill Timoney
— The Pale Man (voice)
Darius Churchman
— Ricco (voice)
Robb Moreira
— The Mayor (voice)
Tom Wayland
— Switchblade (voice)
Lee Baptiste
— Street Lion (voice)
Richard Buckingham Clark
— Rattail
Wayne Grayson
— Rattail (voice)
Ryan Andes
— Additional Voice (voice)
Dan Becker
— Additional Voice (voice)
Nicholas Corda
— Additional Voice (voice)
Hollis Fox
— Additional Voice (voice)
Mike Pollock
— Additional Voice (voice)
Sarah Smithton
— Additional Voice (voice)
Lori Gardner Phillips
— Additional Voice (voice)
Barrett Leddy
— Additional Voice (voice)
Ben Wayland
— Additional Voice (voice)
Finn Wayland
— Additional Voice (voice)
Sharon Mitchell
— Woman on Train (uncredited)
Robert Turano
— Man on Train (uncredited)