Mike Benz
— Will Jordan
Jeff Knite
— Jimmy/Brock Callahan/Flash/Sonny/Self/New anchor #1
Paugh Shadow
— The Copycat Covid Killer
Johnny Careccia
— Krazy Klowny / Healy O' Malley
Jorge Gautier
— The Covid Killer / Bryan / Dereck
Havoc
— Enforcer
Joanne Rullan
— Druggie Cop/ Nurse / Luscious / Penny
Shyann Lorenzana
— Martina Pippen
Dasha Prozorova
— Cassie
Melanie Maldonado
— Captain Felicia Jackson
Roman Suarez
— Chuleta Brother 1
David Taveras
— Chuleta Brother 2
Maruka Diaz
— Internal Affairs Woman
Christine Rondon
— Destiny
Lito Colon
— Mat
Billie Bennett
— Jill
Deanna Giamio
— Sneaker Girl
Jay Doggs
— Jay Doggs / Cap
Artie Cordel
— Pig Vomit Cop
Veronica Knite
— The Covid Killer's Wife / News Anchor #2
Mamu
— Habeeb
Joe Biden
— Self (archive footage) (uncredited)
Andrew Cuomo
— Self (archive footage) (uncredited)
Anthony Fauci
— Self (archive footage) (uncredited)
Nancy Pelosi
— Self (archive footage) (uncredited)
Donald J. Trump
— Self (archive footage) (uncredited)