Marcus M. Mauldin
— The Pope
Michael Shawn Starks
— Michael Angelica
Michael G. Bath
— David Paul Sheba
Maggie Lou Rader
— Beth Sheba
Landon Mergler
— Spiro
Ryan Wesley Gilreath
— Jesse
Daniel Britt
— Gums and Roses
Billy Chace
— Cardinal Cariott
Brian Phillips
— Monsignor Nate Riacco
Mitch Teemley
— Bishop Wisp
Joe Zappa
— Dimitri Leonid Disputin Kamarozov
Ted Weil
— Aloysius Fyodor Pavlonovich "Weebus" Kamarozov
Tess Talbot
— Sommelier
Michael Rowlett
— Young Michael
Farley Norman
— Young David
Isabelle Pope
— Young Beth
Justin McCombs
— Minister
Anne Taylor
— Family member 1
Bob Gerding
— Family member 2
Abi Esmena
— Reporter 1
Brandi Botkin
— Reporter 2
Jenny McManus
— Maid of Honor