Laura Prepon
— Karla Homolka
Misha Collins
— Paul Bernardo
Patrick Bauchau
— Dr. Arnold
Emilie Jacobs
— Peggy
Alex Boyd
— Nick
Tess Harper
— Molly Czehowicz
Leonard Kelly-Young
— Dan Czehowicz
Cherilyn Hayres
— Tammy Homolka
Sarah Foret
— Kaitlyn Ross
Kristen Honey
— Tina McCarthy
Cole James
— Tina's Friend
William Duffy
— Detective Porter
Adam Lieberman
— Detective Morgan
Shawn Hoffman
— Detective Steve Kirby
Tony Denison
— Detective Burroughs
Jeff Doucette
— Burroughs's Partner
Carole Ita White
— Waitress
Fiona Manners
— Rape Victim #1
Tanya Lemelle
— Rape Victim #2
Tony Shawkat
— Border Guard #1
Anna Pheil
— Patricia
Zach DiLiberto
— Doug
Nikki McCauley
— Jessie
Bunny Gibson
— Mrs. Ross
Bradford English
— Mr. Ross
Eileen Dietz
— Helen
Ross Patterson
— Steve
John Ross Clark
— Attorney Warner
Brandon Routh
— Tim
Philippe Bergeron
— Attorney Siegel