Cuba Gooding Jr.
— Mikey
Helen Mirren
— Rose
Vanessa Ferlito
— Vicki
Macy Gray
— Neisha
Joseph Gordon-Levitt
— Dr. Don
Stephen Dorff
— Clayton Mayfield
Mo'Nique
— Precious
Tom Pasch
— Andrew
Ryan Eric Speise
— Anthony - Age 3
Matt Higgins
— Eddie
John Panzarella
— Man in Hotel
Marvina Vinique
— Mikey's Mother
Marilyn Yoblick
— Real Estate Agent
Cullen Flynn Clancy
— Anthony - age 7
Shaun Brewington
— Little Mikey
Darnell Williams
— Mikey's Father
Noel Murano
— A.J.
Angel Oquendo
— Lamar
Tomy Dunster
— Gerard
Jack Krizmanich
— Tommy
Maria Soccor
— Clayton's Girlfriend
Lee Daniels
— Man in Steam Room