Keanu

Jordan Peele

— Rell Williams / Oil Dresden

Keegan-Michael Key

— Clarence Goobril / Smoke Dresden

Keanu Reeves

— Keanu (voice)

Tiffany Haddish

— Hi-C

Method Man

— Cheddar

Darrell Britt-Gibson

— Trunk

Jason Mitchell

— Bud

Jamar Malachi Neighbors

— Stitches

Luis Guzmán

— Bacon

Will Forte

— Hulka

Nia Long

— Hannah

Rob Huebel

— Spencer

Madison Wolfe

— Alexis

Jordyn A. Davis

— Belle

James Yeargain

— Donnie

Brittany Seymour

— Rachel

Richard Holden

— Detective Mank

Nadiyah Skyy Taylor

— Galaxy

Susan McBrien

— Hulka's Mom

Jenny Ballard

— Officer Jonah

Ian Casselberry

— King Diaz

Neil Wells

— Prison Guard

David A. Cole

— Cop #1

Reginal Varice

— Cop #2

Nicholas Hayner

— Guard #2

Anna Faris

— Self (uncredited)

Sam Medina

— Cartel Leader (uncredited)

Gino Galento

— Narco Guard (uncredited)

Maia Kavchak

— Drug Girl (uncredited)

Sue-Lynn Ansari

— Dancer (uncredited)