Jordan Peele
— Rell Williams / Oil Dresden
Keegan-Michael Key
— Clarence Goobril / Smoke Dresden
Keanu Reeves
— Keanu (voice)
Tiffany Haddish
— Hi-C
Method Man
— Cheddar
Darrell Britt-Gibson
— Trunk
Jason Mitchell
— Bud
Jamar Malachi Neighbors
— Stitches
Luis Guzmán
— Bacon
Will Forte
— Hulka
Nia Long
— Hannah
Rob Huebel
— Spencer
Madison Wolfe
— Alexis
Jordyn A. Davis
— Belle
James Yeargain
— Donnie
Brittany Seymour
— Rachel
Richard Holden
— Detective Mank
Nadiyah Skyy Taylor
— Galaxy
Susan McBrien
— Hulka's Mom
Jenny Ballard
— Officer Jonah
Ian Casselberry
— King Diaz
Neil Wells
— Prison Guard
David A. Cole
— Cop #1
Reginal Varice
— Cop #2
Nicholas Hayner
— Guard #2
Anna Faris
— Self (uncredited)
Sam Medina
— Cartel Leader (uncredited)
Gino Galento
— Narco Guard (uncredited)
Maia Kavchak
— Drug Girl (uncredited)
Sue-Lynn Ansari
— Dancer (uncredited)